Integrative Analyses Identify KCNJ15 as a Candidate Gene in Patients with Epilepsy.

ABSTRACT:

Introduction

Although there is accumulating evidence that genetic factors play a vital role in the pathogenesis of epilepsy, few epilepsy-associated genes have been identified. Additionally, the role of KCNJ15 in epilepsy has not been evaluated so far.

Methods

Here, we performed differentially expressed gene analysis, expression quantitative trait loci analysis, gene co-expression analysis, and protein-protein interaction analysis to evaluate the role of KCNJ15 in epilepsy.

Results

Analysis of gene expression and expression quantitative trait loci data revealed that KCNJ15 was significantly downregulated in patients with epilepsy (adjusted P = 0.0146 and log₂ Fold change = - 1.0025), and an epilepsy-associated polymorphism (rs2833098) was linked to altered

SUBMITTER: Wang S 

PROVIDER: S-EPMC9588107 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature