Rotator cuff healing is regulated by the lymphatic vasculature.

ABSTRACT:

Background

Despite great advances in surgical techniques for rotator cuff tear (RCT) over the past decades, the postoperative failure rate of RCT is still high due to the poor healing competence of bone-tendon interface (BTI). The lymphatic vasculature plays a regulatory role in inflammatory disease and affects tissue healing. However, whether lymphangiogenesis and the role of lymphatic vasculature in the physiopathological process of rotator cuff （RC）injury remains unknown.

Methods

In this study, we constructed a mouse RC injury model and the BTI samples were collected for measurement. Firstly, immunofluorescence was used to investigate the temporal and spatial distribution of lymphangiogenesis in BTI area at different post-injury time points. Subsequently, the mice of expe

SUBMITTER: Tong X 

PROVIDER: S-EPMC9593253 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature