Efficacy of metformin therapy in patients with cancer: a meta-analysis of 22 randomised controlled trials.

ABSTRACT:

Background

To investigate whether metformin monotherapy or adjunctive therapy improves the prognosis in patients with any type of cancer compared to non-metformin users (age ≥18).

Methods

Databases (Medline, Embase, and the Cochrane Central Register of Controlled Trials) and clinical trial registries ( ClinicalTrials.gov ; the World Health Organization International Clinical Trials Registry Platform) were screened for randomized, controlled trials (RCT) reporting at least progression-free survival (PFS) and/or overall survival (OS). Main outcome measures included hazard ratios (HR), and combined HRs and 95% confidence intervals (CI) were calculated using random-effects models.

Results

Of the 8419 records screened, 22 RCTs comprising 5943 participants were included. Po

SUBMITTER: Wen J 

PROVIDER: S-EPMC9594974 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature