Dataset Information
Pilot-RCT Finds No Evidence for Modulation of Neuronal Networks of Auditory Hallucinations by Transcranial Direct Current Stimulation.
Ontology highlight
ABSTRACT: Background
Transcranial direct current stimulation (tDCS) is used as treatment for auditory verbal hallucinations (AVH). The theory behind the treatment is that tDCS increases activity in prefrontal cognitive control areas, which are assumed to be hypoactive, and simultaneously decreases activity in temporal speech perception areas, which are assumed to be hyperactive during AVH. We tested this hypofrontal/hypertemporal reversal theory by investigating anatomical, neurotransmitter, brain activity, and network connectivity changes over the course of tDCS treatment.Methods
A double-blind, randomized controlled trial was conducted with 21 patients receiving either sham or real tDCS treatment (2 mA) twice daily for 5 days. The anode was placed over the left dorsolateral prefrontal cortex (DLPFC) and the cathode over the left temporo-parietal cortex (TPC). Multimodal neuroimaging as well as clinical and neurocognitive functioning assessment were performed before, immediately after, and three months after treatment.Results
We found a small reduction in AVH severity in the real tDCS group, but no corresponding neuroimaging changes in either DLPFCD or TPC.Limitations
The study has a small sample size.Conclusion
The results suggest that the currently leading theory behind tDCS treatment of AVH may need to be revised, if confirmed by studies with larger N. Tentative findings point to the involvement of Broca's area as a critical structure for tDCS treatment.
SUBMITTER: Marquardt L
PROVIDER: S-EPMC9599056 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Publications
Pilot-RCT Finds No Evidence for Modulation of Neuronal Networks of Auditory Hallucinations by Transcranial Direct Current Stimulation.
Brain sciences 20221012 10
<h4>Background</h4>Transcranial direct current stimulation (tDCS) is used as treatment for auditory verbal hallucinations (AVH). The theory behind the treatment is that tDCS <i>increases</i> activity in prefrontal cognitive control areas, which are assumed to be <i>hypo</i>active, and simultaneously <i>decreases</i> activity in temporal speech perception areas, which are assumed to be <i>hyper</i>active during AVH. We tested this hypofrontal/hypertemporal reversal theory by investigating anatomi ...[more]