Ontology highlight
ABSTRACT:
SUBMITTER: Canoy RJ
PROVIDER: S-EPMC9600575 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Canoy Reynand Jay RJ Shmakova Anna A Karpukhina Anna A Shepelev Mikhail M Germini Diego D Vassetzky Yegor Y
Cancers 20221018 20
Chromosomal translocations are products of the illegitimate repair of DNA double-strand breaks (DSBs). Their formation can bring about significant structural and molecular changes in the cell that can be physiologically and pathologically relevant. The induced changes may lead to serious and life-threatening diseases such as cancer. As a growing body of evidence suggests, the formation of chromosomal translocation is not only affected by the mere close spatial proximity of gene loci as potential ...[more]