Chromosomal Translocations Detection in Cancer Cells Using Chromosomal Conformation Capture Data.

ABSTRACT: Complex chromosomal rearrangements such as translocations play a critical role in oncogenesis. Translocation detection is vital to decipher their biological role in activating cancer-associated mechanisms. High-throughput chromosomal conformations capture (Hi-C) data have shown promising progress in unveiling the genome variations in a disease condition. Until now, multiple structural data (Hi-C)-based methods are available that can detect translocations in cancer genomes. However, the consistency and specificity of Hi-C-based translocation results still need to be validated with conventional methods. This study used Hi-C data of cancerous cell lines, namely lung cancer (A549), Chronic Myelogenous Leukemia (K562), and Acute Monocytic Leukemia (THP-1), to detect the translocations. The resu

SUBMITTER: Adeel MM 

PROVIDER: S-EPMC9319866 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature