Emergence of a clone of invasive fucK-negative serotype e Haemophilus influenzae in British Columbia.

ABSTRACT:

Background

Introduction of the Haemophilus influenzae serotype b (Hib) conjugate vaccine has changed the epidemiology of invasive H. influenzae disease, with most infections now caused by non-typeable (non-encapsulated) and non-Hib encapsulated strains.

Methods

We describe nine invasive serotype e H. influenzae (Hie) from British Columbia that were determined to have complete deletion of their fucose operon genes. These nine isolates were recovered from blood cultures of three female and six male patients during 2011-2018, with eight recovered in the past 4 years.

Results

All nine isolates were biotype IV, with eight showing identical pulsed field gel electrophoresis (PFGE) profiles, whereas the ninth showed 95% similarity. PFGE analysis also show

SUBMITTER: Whyte KE 

PROVIDER: S-EPMC9603308 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature