Ontology highlight
ABSTRACT: Purpose
Arterial stiffness is a subclinical marker of cardiovascular disease (CVD). The pre-frailty phenotype is associated with a higher risk for CVD. This study investigated the association between the pre-frailty phenotype and arterial stiffness in community-dwelling older adults without diagnosed CVD.Methods
In total, 249 community-dwelling older adults aged 60-80 years were included in this cross-sectional study. The pre-frailty phenotype was defined by the standardized Fried criteria (muscle weakness; slow walking speed; low physical activity; unintentional weight loss; self-reported exhaustion). Participants with one or two standardized Fried criteria were classified as pre-frail and those with zero criteria as robust. Arterial stiffness was measured by aortic pulse wave velocity (aPWV). The data were analyzed using the generalized linear model.Results
From 249 participants (66.1 ± 5.3 years; 79.5% females), 61.8% (n = 154) were pre-frail and 38.2% (n = 95) robust. Pre-frail older adults had a higher aPWV (β = 0.19 m/s; p = 0.007) compared to their robust peers.Conclusions
The pre-frailty phenotype was associated with higher arterial stiffness in community-dwelling older adults aged 60-80 years. Pre-frail older adults may have a higher risk for CVD.
SUBMITTER: Macedo GAD
PROVIDER: S-EPMC9603482 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Macêdo Geovani Araújo Dantas GAD Freire Yuri Alberto YA Browne Rodrigo Alberto Vieira RAV Câmara Marcyo M Cabral Ludmila Lucena Pereira LLP Schwade Daniel D Paulo-Pereira Ronildo R Silva Raíssa de Melo RM Silva Alana Monteiro Bispo AMB Farias-Junior Luiz Fernando LF Duhamel Todd A TA Costa Eduardo Caldas EC
International journal of environmental research and public health 20221018 20
<h4>Purpose</h4>Arterial stiffness is a subclinical marker of cardiovascular disease (CVD). The pre-frailty phenotype is associated with a higher risk for CVD. This study investigated the association between the pre-frailty phenotype and arterial stiffness in community-dwelling older adults without diagnosed CVD.<h4>Methods</h4>In total, 249 community-dwelling older adults aged 60-80 years were included in this cross-sectional study. The pre-frailty phenotype was defined by the standardized Frie ...[more]