Association of IGF1 polymorphisms with exotropia in a Pakistani cohort.

ABSTRACT:

Purpose

Strabismus (STBMS) is a multifactorial ocular disorder in children that leads to misalignment of the eyes. Insulin-like growth factor 1 (IGF1) has been shown to be involved in the development of extraocular muscles and myopia; however, data are limited on the genetic associations of IGF1 with STBMS in Pakistan.

Methods

Two hundred seventy-four STBMS cases and 272 unaffected controls were recruited, and their DNA was extracted. Two IGF1 single nucleotide polymorphisms, rs6214 and rs5742632, were genotyped using PCR-restriction fragment length polymorphism. Univariate logistic regression analysis was performed to determine the association of these single nucleotide polymorphisms with STBMS, and the results were adjusted for age and sex. In addition

SUBMITTER: Zehra Z 

PROVIDER: S-EPMC9603902 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature