Emerging Roles of RNA-Binding Proteins in Inner Ear Hair Cell Development and Regeneration.

ABSTRACT: RNA-binding proteins (RBPs) regulate gene expression at the post-transcriptional level. They play major roles in the tissue- and stage-specific expression of protein isoforms as well as in the maintenance of protein homeostasis. The inner ear is a bi-functional organ, with the cochlea and the vestibular system required for hearing and for maintaining balance, respectively. It is relatively well documented that transcription factors and signaling pathways are critically involved in the formation of inner ear structures and in the development of hair cells. Accumulating evidence highlights emerging functions of RBPs in the post-transcriptional regulation of inner ear development and hair cell function. Importantly, mutations of splicing factors of the RBP family and defective alternative spl

SUBMITTER: Shi DL 

PROVIDER: S-EPMC9604452 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature