Peripheral Blood Monocyte Abundance Predicts Outcomes in Patients with Breast Cancer.

ABSTRACT: Biomarkers of response are needed in breast cancer to stratify patients to appropriate therapies and avoid unnecessary toxicity. We used peripheral blood gene expression and cell type abundance to identify biomarkers of response and recurrence in neoadjuvant chemotherapy treated breast cancer patients. We identified a signature of interferon and complement response that was higher in the blood of patients with pathologic complete response. This signature was preferentially expressed by monocytes in single cell RNA sequencing. Monocytes are routinely measured clinically, enabling examination of clinically measured monocytes in multiple independent cohorts. We found that peripheral monocytes were higher in patients with good outcomes in four cohorts of breast cancer patients. Blood gene expr

SUBMITTER: Axelrod ML 

PROVIDER: S-EPMC9604512 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature