Ontology highlight
ABSTRACT: Significance
Biomarkers are needed in breast cancer to identify patients at risk for recurrence. Blood is an attractive site for biomarker identification due to the relative ease of longitudinal sampling. Our study suggests that blood-based gene expression and cell type abundance biomarkers may have clinical utility in breast cancer.
SUBMITTER: Axelrod ML
PROVIDER: S-EPMC9604512 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Axelrod Margaret L ML Wang Yu Y Xu Yaomin Y Sun Xiaopeng X Bejan Cosmin A CA Gonzalez-Ericsson Paula I PI Nunnery Sara S Bergman Riley E RE Donaldson Joshua J Guerrero-Zotano Angel L AL Massa Chiara C Seliger Barbara B Sanders Melinda M Mayer Ingrid A IA Balko Justin M JM
Cancer research communications 20220504 5
Biomarkers of response are needed in breast cancer to stratify patients to appropriate therapies and avoid unnecessary toxicity. We used peripheral blood gene expression and cell type abundance to identify biomarkers of response and recurrence in neoadjuvant chemotherapy treated breast cancer patients. We identified a signature of interferon and complement response that was higher in the blood of patients with pathologic complete response. This signature was preferentially expressed by monocytes ...[more]