Shared biophysical mechanisms determine early biofilm architecture development across different bacterial species.

ABSTRACT: Bacterial biofilms are among the most abundant multicellular structures on Earth and play essential roles in a wide range of ecological, medical, and industrial processes. However, general principles that govern the emergence of biofilm architecture across different species remain unknown. Here, we combine experiments, simulations, and statistical analysis to identify shared biophysical mechanisms that determine early biofilm architecture development at the single-cell level, for the species Vibrio cholerae, Escherichia coli, Salmonella enterica, and Pseudomonas aeruginosa grown as microcolonies in flow chambers. Our data-driven analysis reveals that despite the many molecular differences between these species, the biofilm architecture differences can be described by only 2 control paramet

SUBMITTER: Jeckel H 

PROVIDER: S-EPMC9605341 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature