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Ignatzschineria indica bloodstream infection associated with maggot infestation of a wound in a patient from Canada.

ABSTRACT: We describe a case of Ignatzschineria indica bacteremia in a patient with maggot infestation of a necrotic left leg wound. Ignatzschineria spp are an infrequent cause of infection in patients with wound myiasis. We review 16 cases described in published literature. Microbiologists and clinicians should be aware of uncommon bacteria, including Ignatzschineria spp, that may cause infection in patients with maggot-infested wounds such that these organisms are appropriately worked up and treated when found in clinical specimens.

SUBMITTER: Fear T

PROVIDER: S-EPMC9608726 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Ignatzschineria indica bloodstream infection associated with maggot infestation of a wound in a patient from Canada.

Fear Thomas T Richert Quinn Q Levesque Jasmine J Walkty Andrew A Keynan Yoav Y

Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada 20201011 3

We describe a case of Ignatzschineria indica bacteremia in a patient with maggot infestation of a necrotic left leg wound. Ignatzschineria spp are an infrequent cause of infection in patients with wound myiasis. We review 16 cases described in published literature. Microbiologists and clinicians should be aware of uncommon bacteria, including Ignatzschineria spp, that may cause infection in patients with maggot-infested wounds such that these organisms are appropriately work ...[more]

PMID: 36341319

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Project description:BackgroundDiabetic skin wound is a complex problem due to the disruption of normal repairing program and lack of effective remedy. Lucilia sericata larvae (maggot) is a folk method to treat chronic skin wound, while its therapeutic effects on that caused by diabetic remains unknown.ObjectiveThis study aims to investigate the therapeutic effects of maggot extract (M.E.) on diabetic skin wound and its molecular mechanism by establishing the skin wound model of diabetic Sprague Dawley (SD) rats.MethodsDiabetic model was established by injecting intraperitoneally streptozotocin in SD rats under specific pathogen-free (SPF) conditions. The rat fasting blood glucose values were ≧16.7 mmol/L 72 hours after intraperitoneal streptozotocin (60mg/kg body weight) injection. The rats were divided into five groups (n = 10/group): normal group: normal SD rats without any treatment, diabetic blank group: the diabetic rats without any treatment, Vaseline group: the diabetic rats dressed with Vaseline, recombinant human epidermal-growth-factor (rhEGF) group: the diabetic rats dressed with a mixture of Vaseline and 200 μg/g rhEGF, M.E. group: the diabetic rats dressed with a mixture of Vaseline and 150 μg/ml maggot extract. The round open wounds (1.0 cm in diameter) down to the muscle fascia were made on both sides of rat dorsa by removing the skin layer (epidermis and dermis) and were daily photographed for calculating their healing rates. Hematoxylin-eosin (HE) and Masson's trichrome staining were performed on skin wound sections to analyze re-epithelialization and granulation tissue formation. Immunohistochemical (IHC), immunofluorescent (IF) stainings and Western blotting were conducted to analyze the statuses of STAT3 signaling.ResultsThe average wound healing rates on the 14th day were 91.7% in the normal, 79.6% in M.E., 71% in rhEGF, 55.1% in vaseline and 43.3% in the diabetes blank group. Morphological staining showed more active granulation tissue formation, re-epithelialization and neovascularization in M.E.-group than those in the blank and the vaseline-treated groups. Decreased p-STAT3 nuclear tranlocation and down-regulated Bcl-2, CyclinD1 and vascular endothelial growth factor (VEGF) expression were evidenced in the diabetic rats, which could be improved by rhEGF and especially M.E.ConclusionMaggot extract would be an alternative and/or adjuvant candidate for the better management of diabetic skin wounds because of its activity in enhancing STAT3 activation.

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Ignatzschineria indica bloodstream infection associated with maggot infestation of a wound in a patient from Canada.

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<i>Ignatzschineria indica</i> bloodstream infection associated with maggot infestation of a wound in a patient from Canada.

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