Ontology highlight
ABSTRACT:
SUBMITTER: Chalapathi D
PROVIDER: S-EPMC9609503 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Chalapathi Divya D Kumar Amrendra A Behera Pratik P Sathi Shijulal Nelson SN Swaminathan Rajaram R Narayana Chandrabhas C
Molecules (Basel, Switzerland) 20221021 20
Protein misfolding and aggregation play a significant role in several neurodegenerative diseases. In the present work, the spontaneous aggregation of hen egg-white lysozyme (HEWL) in an alkaline pH 12.2 at an ambient temperature was studied to obtain molecular insights. The time-dependent changes in spectral peaks indicated the formation of β sheets and their effects on the backbone and amino acids during the aggregation process. Introducing iodoacetamide revealed the crucial role of intermolecu ...[more]