Novel Stenotrophomonas maltophilia Bacteriophage as Potential Therapeutic Agent.

ABSTRACT: A novel bacteriophage CUB19 specific to the bacterial species Stenotrophomonas maltophilia was isolated from hospital sewage and characterized as a new species belonging to a proposed new phage genus 'Cubvirus' (Caudoviricetes). Its genome contains a total of 48,301 bp and 79 predicted genes, among which some have been associated with packaging and lysis-associated proteins, structural proteins, or DNA- and metabolism-associated proteins. No lysogeny-associated proteins or known virulence proteins were identified on the phage genome. CUB19 showed stability over a wide range of temperatures (-20 °C-60 °C) and pH values (pH 3-pH 13). Despite its narrow host range, this phage has potent observed antimicrobial and antibiofilm activity. A time-killing curve assay showed significan

SUBMITTER: Fanaei Pirlar R 

PROVIDER: S-EPMC9612306 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature