Cerebral glucose changes after chemotherapy and their relation to long-term cognitive complaints and fatigue.

ABSTRACT:

Purpose

To investigate the short-term cerebral metabolic effects of intravenous chemotherapy and their association with long-term fatigue/cognitive complaints.

Experimental design

Using [¹⁸F]-FDG-PET/CT whole-body scans, we retrospectively quantified relative cerebral glucose metabolism before and after neoadjuvant chemotherapy in a cohort of patients treated for non-metastatic breast cancer (2009-2019). Self-report of cognitive complaints and fatigue were prospectively assessed 7 ± 3 years after therapy. Metabolic changes were estimated with i) robust mixed-effects modelling in regions-of-interest (frontal, parietal, temporal, occipital, and insular cortex) and ii) general-linear modelling of whole-brain voxel-wise outcomes. iii) The association between metabolic

SUBMITTER: Schroyen G 

PROVIDER: S-EPMC9612406 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature