Cerebral amyloid deposition predicts long-term cognitive decline in hemorrhagic small vessel disease.

ABSTRACT:

Background

To investigate the association between cerebral amyloid deposition and long-term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) and survivors of intracerebral hemorrhage (ICH).

Methods

Patients experiencing an ICH without overt dementia were prospectively recruited (n = 68) for brain MRI and Pittsburgh compound B (PiB) positron emission tomography scans at baseline. Cognitive function was assessed using the mini-mental status examination (MMSE) and clinical dementia rating after an overall median follow-up of 3.8 years. A positive amyloid scan was defined as a global PiB standardized uptake value ratio >1.2. Associations between follow-up cognitive outcomes and neuroimaging markers were explored using multivariable Cox regression models

SUBMITTER: Tsai YC 

PROVIDER: S-EPMC10570474 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature