Dataset Information

Cerebral amyloid deposition predicts long-term cognitive decline in hemorrhagic small vessel disease.

ABSTRACT:

Background

To investigate the association between cerebral amyloid deposition and long-term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) and survivors of intracerebral hemorrhage (ICH).

Methods

Patients experiencing an ICH without overt dementia were prospectively recruited (n = 68) for brain MRI and Pittsburgh compound B (PiB) positron emission tomography scans at baseline. Cognitive function was assessed using the mini-mental status examination (MMSE) and clinical dementia rating after an overall median follow-up of 3.8 years. A positive amyloid scan was defined as a global PiB standardized uptake value ratio >1.2. Associations between follow-up cognitive outcomes and neuroimaging markers were explored using multivariable Cox regression models.

Results

PiB(+) patients were older (72.1 ± 7.8 vs. 59.9 ± 11.7, p = .002) and more frequently had cerebral amyloid angiopathy (CAA) (63.6% vs. 15.8%, p = .002) than PiB(-) patients. PiB(+) was associated with a higher risk of dementia conversion (32.9 vs. 4.0 per 100-person-years, hazard ratio [HR] = 15.7 [3.0-80.7], p = .001) and MMSE score decline (58.8 vs. 9.9 per 100-person-years, HR = 6.2 [1.9-20.0], p = .002). In the non-CAA subgroup (n = 52), PiB(+) remained an independent predictor of dementia conversion, p = .04). In the Cox models, PiB(+) was an independent predictor of dementia conversion (HR = 15.8 [2.6-95.4], p = .003) and MMSE score decline (HR = 5.7 [1.6-20.3], p = .008) after adjusting for confounders.

Conclusions

Cerebral amyloid deposition potentially contributes to long-term cognitive decline in SVD-related ICH.

SUBMITTER: Tsai YC

PROVIDER: S-EPMC10570474 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Publications

Cerebral amyloid deposition predicts long-term cognitive decline in hemorrhagic small vessel disease.

Tsai Ya-Chin YC Tsai Hsin-Hsi HH Liu Chia-Ju CJ Lin Sheng-Sian SS Chen Ya-Fang YF Jeng Jiann-Shing JS Tsai Li-Kai LK Yen Ruoh-Fang RF

Brain and behavior 20230802 10

<h4>Background</h4>To investigate the association between cerebral amyloid deposition and long-term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) and survivors of intracerebral hemorrhage (ICH).<h4>Methods</h4>Patients experiencing an ICH without overt dementia were prospectively recruited (n = 68) for brain MRI and Pittsburgh compound B (PiB) positron emission tomography scans at baseline. Cognitive function was assessed using the mini-mental status examination (MMS ...[more]

PMID: 37533346

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Dataset Information

Cerebral amyloid deposition predicts long-term cognitive decline in hemorrhagic small vessel disease.

Background

Methods

Results

Conclusions

Publications

Cerebral amyloid deposition predicts long-term cognitive decline in hemorrhagic small vessel disease.

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