Dataset Information

The association of global vessel width with cognitive decline and cerebral small vessel disease burden in the KaiLuan study.

ABSTRACT:

Background

As the retinal microvasculature shares similarities with the cerebral microvasculature, numerous studies have shown that retinal vascular is associated with cognitive decline. In addition, several population-based studies have confirmed the association between retinal vascular and cerebral small vessel disease (CSVD) burden. However, the association of retinal vascular with CSVD burden as well as cognitive function has not been explored simultaneously. This study investigated the relations of retinal microvascular parameters (RMPs) with CSVD burden and cognitive function.

Methods

We conducted a cross-sectional study of participants in the KaiLuan study. Data were collected from subjects aged ≥18 years old who could complete retinal photography and brain magnetic resonance imaging (MRI) between December 2020 to October 2021 in the Kailuan community of Tangshan. RMPs were evaluated using a deep learning system. The cognitive function was measured using the Montreal Cognitive Assessment (MoCA). We conducted logistic regression models, and mediation analysis to evaluate the associations of RMPs with CSVD burden and cognitive decline.

Results

Of the 905 subjects (mean age: 55.42±12.02 years, 54.5% female), 488 (53.9%) were classified with cognitive decline. The fractal dimension (FD) [odds ratio (OR), 0.098, 95% confidence interval (CI): 0.015-0.639, P=0.015] and global vein width (OR: 1.010, 95% CI: 1.005-1.015, P<0.001) were independent risk factors for cognitive decline after adjustment for potential confounding factors. The global artery width was significantly associated with severe CSVD burden (OR: 0.985, 95% CI: 0.974-0.997, P=0.013). The global vein width was sightly associated with severe CSVD burden (OR: 1.005, 95% CI: 1.000-1.010, P=0.050) after adjusting for potential confounders. The multivariable-adjusted odds ratios (95% CI) in highest tertile versus lowest tertile of global vein width were 1.290 (0.901-1.847) for cognitive decline and 1.546 (1.004-2.290) for severe CSVD burden, respectively. Moreover, CSVD burden played a partial mediating role in the association between global vein width and cognitive function (mediating effect 6.59%).

Conclusions

RMPs are associated with cognitive decline and the development of CSVD. A proportion of the association between global vein width and cognitive decline may be attributed to the presence of CSVD burden.

SUBMITTER: Li R

PROVIDER: S-EPMC10784051 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

The association of global vessel width with cognitive decline and cerebral small vessel disease burden in the KaiLuan study.

Li Rui R Hui Ying Y Li Jing J Zhang Xiaoyue X Zhang Shun S Lv Bin B Ni Yuan Y Li Xiaoshuai X Liang Xiaoliang X Yang Ling L Lv Han H Li Hongyang H Yang Yingping Y Liu Guangfeng G Xie Guotong G Wu Shouling S Wang Zhenchang Z

Quantitative imaging in medicine and surgery 20240102 1

<h4>Background</h4>As the retinal microvasculature shares similarities with the cerebral microvasculature, numerous studies have shown that retinal vascular is associated with cognitive decline. In addition, several population-based studies have confirmed the association between retinal vascular and cerebral small vessel disease (CSVD) burden. However, the association of retinal vascular with CSVD burden as well as cognitive function has not been explored simultaneously. This study investigated ...[more]

PMID: 38223087

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Project description:The factors and mechanisms underlying the heterogeneous cognitive outcomes of cerebral small vessel disease are largely unknown. Brain biological age can be estimated by machine learning algorithms that use large brain MRI data sets to integrate and compute neuroimaging-derived age-related features. Predicted and chronological ages difference (brain-age gap) reflects advanced or delayed brain aging in an individual. The present study firstly reports the brain aging status of cerebral small vessel disease. In addition, we investigated whether global or certain regional brain age could mediate the cognitive functions in cerebral small vessel disease. Global and regional (400 cortical, 14 subcortical and 28 cerebellum regions of interest) brain-age prediction models were constructed using grey matter features from MRI of 1482 healthy individuals (age: 18-92 years). Predicted and chronological ages differences were obtained and then applied to non-stroke, non-demented individuals, aged ≥50 years, from another community-dwelling population (I-Lan Longitudinal Aging Study cohort). Among the 734 participants from the I-Lan Longitudinal Aging Study cohort, 124 were classified into the cerebral small vessel disease group. The cerebral small vessel disease group demonstrated significantly poorer performances in global cognitive, verbal memory and executive functions than that of non-cerebral small vessel disease group. Global brain-age gap was significantly higher in the cerebral small vessel disease (3.71 ± 7.60 years) than that in non-cerebral small vessel disease (-0.43 ± 9.47 years) group (P = 0.003, η2 = 0.012). There were 82 cerebral cortical, 3 subcortical and 4 cerebellar regions showing significantly different brain-age gap between the cerebral small vessel disease and non-cerebral small vessel disease groups. Global brain-age gap failed to mediate the relationship between cerebral small vessel disease and any of the cognitive domains. In 89 regions with increased brain-age gap in the cerebral small vessel disease group, seven regional brain-age gaps were able to show significant mediation effects in cerebral small vessel disease-related cognitive impairment (we set the statistical significance P < 0.05 uncorrected in 89 mediation models). Of these, the left thalamus and left hippocampus brain-age gap explained poorer global cognitive performance in cerebral small vessel disease. We demonstrated the interconnections between cerebral small vessel disease and brain age. Strategic brain aging, i.e. advanced brain aging in critical regions, may be involved in the pathophysiology of cerebral small vessel disease-related cognitive impairment. Regional rather than global brain-age gap could potentially serve as a biomarker for predicting heterogeneous cognitive outcomes in patients with cerebral small vessel disease.

Project description:IntroductionCerebral small vessel disease (CSVD) is highly prevalent in elder individuals, and its variable cognitive outcomes indicate some cognitive reserve mechanisms. Contribution from functional network features is still unclear. Here we explore how functional segregation-integration preference influences the cognitive changes against CSVD.Materials and methodsA total of, 271 CSVD patients were included, all underwent MRI scans including routine and resting-state functional MRI (rs-fMRI). Hierarchical balance index (HB) was obtained from the rs-fMRI connectivity using eigenmode-based approach. Individuals were classified into segregated and integrated groups according to negative and positive HB. A composite CSVD lesion score was calculated from imaging findings. Global and five specific cognitive functions were assessed.ResultsHierarchical regression analysis revealed negative contribution from lesion load to global and all cognitive domains (β = -0.22~-0.35, ∆R2 = 0.046~0.112, all p < 0.001). Inclusion of HB did not show significant contribution (all p > 0.05), but interaction between HB and lesion score was significantly associated with global (β = -0.27, ∆R2 = 0.013, p = 0.034) and execution score (β = -0.34, ∆R2 = 0.023, p = 0.002). Integrated patients show significant better global cognitive (23.9 ± 3.9 vs. 25.5 ± 3.1, p = 0.044) and executive ability (0.235 ± 0.678 vs. 0.535 ± 0.688, p = 0.049) at mild damage stage, visuospatial (-0.001 ± 0.804 vs. 0.379 ± 0.249, p = 0.034) and language ability (-0.133 ± 0.849 vs. 0.218 ± 0.704, p = 0.037) at moderate damage stage. Cross-overs of cognitive scores were observed. Significant better execution (-0.277 ± 0.717 vs. -0.675 ± 0.883, p = 0.027) was found in severe damage stage for segregated patients.ConclusionThus, we concluded that integrated network contributes to cognitive resilience in mild and moderate but not in severe damage stages.

Dataset Information

The association of global vessel width with cognitive decline and cerebral small vessel disease burden in the KaiLuan study.

Background

Methods

Results

Conclusions

Publications

The association of global vessel width with cognitive decline and cerebral small vessel disease burden in the KaiLuan study.

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