Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy.
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ABSTRACT:
SUBMITTER: Ma S
PROVIDER: S-EPMC9612852 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Publications
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy.
Ma Shoubao S Caligiuri Michael A MA Yu Jianhua J
Trends in immunology 20220901 10
Natural killer (NK) cells, a crucial component of the innate immune system, have long been of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is regulated by interleukin-15 (IL-15), a cytokine in the common γ-chain family. Several current clinical trials are using IL-15 or its analogs to treat various cancers. Moreover, NK cells are being genetically modified to produce membrane-bound or secretory IL-15. Here, we discuss the key role of IL-15 signaling i ...[more]
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