Mitotic kinase oscillation governs the latching of cell cycle switches.

ABSTRACT: In 1996, Kim Nasmyth¹ proposed that the eukaryotic cell cycle is an alternating sequence of transitions from G₁ to S-G₂-M and back again. These two phases correlate to high activity of cyclin-dependent kinases (CDKs) that trigger S-G₂-M events and CDK antagonists that stabilize G₁ phase. We associated these "alternative phases" with the coexistence of two stable steady states of the biochemical reactions among CDKs and their antagonists.^2,3 Transitions between these steady states (G₁-to-S and M-to-G₁) are driven by "helper" proteins. The fact that the transitions are irreversible is guaranteed by a "latching" property of the molecular switches, as we have argued in previous publica

SUBMITTER: Novak B 

PROVIDER: S-EPMC9616797 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature