Dataset Information

Trimester-specific prenatal heavy metal exposures and sex-specific postpartum size and growth.

ABSTRACT:

Background

There has been limited research considering the effects of prenatal exposure to multiple heavy metals on early childhood size and growth.

Objective

We evaluated prenatal exposures to 15 heavy metals in association with measures of weight, length, and head circumference (HC) measured at birth, and 1, 3 and 6 months of age in a study of 358 mother-child pairs.

Methods

Urinary concentrations were measured in the first and third trimesters of pregnancy and examined, using sex-stratified general linear models, in association with average standardized size and changes in size (growth) over the first 6 months of life. Confounding effects among metals were explored.

Results

Increased first trimester Hg and V were associated with decreased average HC among males and weight among females, respectively. Increased first trimester V was associated with a decline in weight among females over time. Increased third trimester Cs, Rb and Tl were associated with increased average weight and HC among males. Increased third trimester Se was associated with increased HC among females over time. Evidence for confounding was observed between Cs, Rb and Tl in association with weight and HC.

Significance

We observed multiple biologically plausible associations between prenatal heavy metal exposures and postnatal size and growth.

Impact

We have taken a comprehensive and novel approach to evaluating the impacts of prenatal heavy metal exposures on size and growth during early childhood. Our detailed analyses consider exposures to 15 different heavy metals at two time points during pregnancy, as well as multiple metrics of size and growth collected at birth and 1, 3 and 6 months of age.

SUBMITTER: Yao L

PROVIDER: S-EPMC9617807 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

Trimester-specific prenatal heavy metal exposures and sex-specific postpartum size and growth.

Yao Lena L Liu Lili L Dong Ming M Yang Jinmei J Zhao Zhiqiang Z Chen Jiabin J Lv Lijuan L Wu Zhaoxia Z Wang Jin J Sun Xin X Self Steven S Bhatti Parveen P

Journal of exposure science & environmental epidemiology 20220430 6

<h4>Background</h4>There has been limited research considering the effects of prenatal exposure to multiple heavy metals on early childhood size and growth.<h4>Objective</h4>We evaluated prenatal exposures to 15 heavy metals in association with measures of weight, length, and head circumference (HC) measured at birth, and 1, 3 and 6 months of age in a study of 358 mother-child pairs.<h4>Methods</h4>Urinary concentrations were measured in the first and third trimesters of pregnancy and examined, ...[more]

PMID: 35490160

Similar Datasets

Project description:BACKGROUND:Bisphenol A (BPA) is an endocrine disruptor that affects fetal growth in experimental studies. Bisphenol F (BPF) and bisphenol S (BPS), which have been substituted for BPA in some consumer products, have also shown endocrine-disrupting effects in experimental models. However, the effects of BPF and BPS on fetal growth in humans are unknown. OBJECTIVES:Our goal was to investigate trimester-specific associations of urinary concentrations of BPA, BPF, and BPS with size at birth. METHODS:The present study included 845 pregnant women from Wuhan, China (2013-2015), who provided one urine sample in each of the first, second, and third trimesters. Linear regressions with generalized estimating equations were applied to estimate trimester-specific associations of urinary bisphenol concentrations with birth weight, birth length, and ponderal index. Linear mixed-effects models were used to identify potential critical windows of susceptibility to bisphenols by comparing the exposure patterns of newborns in the 10th percentile of each birth anthropometric measurement to that of those in the 90th percentile. RESULTS:Medians (25th-75th percentiles) of urinary concentrations of BPA, BPF, and BPS were 1.40 (0.19-3.85), 0.65 (0.34-1.39), and 0.38 (0.13-1.11) ng/mL, respectively. Urinary BPA concentrations in different trimesters were inversely, but not significantly, associated with birth weight and ponderal index. Urinary concentrations of BPF and BPS during some trimesters were associated with significantly lower birth weight, birth length, or ponderal index, with significant trend p-values (ptrend<0.05) across quartiles of BPF and BPS concentrations. The observed associations were unchanged after additionally adjusting for other bisphenols. In addition, newborns in the 10th percentile of each birth anthropometry measure had higher BPF and BPS exposures during pregnancy than newborns in the 90th percentile of each outcome. CONCLUSIONS:Prenatal exposure to BPF and BPS was inversely associated with size at birth in this cohort. Replication in other populations is needed. https://doi.org/10.1289/EHP4664.

Dataset Information

Trimester-specific prenatal heavy metal exposures and sex-specific postpartum size and growth.

Background

Objective

Methods

Results

Significance

Impact

Publications

Trimester-specific prenatal heavy metal exposures and sex-specific postpartum size and growth.

Similar Datasets

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