Human neutrophil development and functionality are enabled in a humanized mouse model.
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ABSTRACT:
SUBMITTER: Zheng Y
PROVIDER: S-EPMC9618085 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Publications
Human neutrophil development and functionality are enabled in a humanized mouse model.
Zheng Yunjiang Y Sefik Esen E Astle John J Karatepe Kutay K Öz Hasan H HH Solis Angel G AG Jackson Ruaidhrí R Luo Hongbo R HR Bruscia Emanuela M EM Halene Stephanie S Shan Liang L Flavell Richard A RA
Proceedings of the National Academy of Sciences of the United States of America 20221021 43
Mice with a functional human immune system serve as an invaluable tool to study the development and function of the human immune system in vivo. A major technological limitation of all current humanized mouse models is the lack of mature and functional human neutrophils in circulation and tissues. To overcome this, we generated a humanized mouse model named MISTRGGR, in which the mouse granulocyte colony-stimulating factor (G-CSF) was replaced with human G-CSF and the mouse G-CSF receptor gene w ...[more]
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