Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8⁺ T cell subsets.

ABSTRACT: Interleukin-15 (IL-15) is often considered a central regulator of memory CD8⁺ T cells, based primarily on studies of recirculating subsets. However, recent work identified IL-15-independent CD8⁺ T cell memory populations, including tissue-resident memory CD8⁺ T cells (T_RM) in some nonlymphoid tissues (NLTs). Whether this reflects the existence of IL-15-insensitive memory CD8⁺ T cells is unclear. We report that IL-15 complexes (IL-15c) stimulate rapid proliferation and expansion of both tissue-resident and circulating memory CD8⁺ T cell subsets across lymphoid and nonlymphoid tissues with varying magnitude by tissue and memory subset, in some sites correlating with differing levels of the IL-2Rβ. This was conserved for memory

SUBMITTER: Jarjour NN 

PROVIDER: S-EPMC9618124 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature