Collagen cross-link profiles and mineral are different between the mandible and femur with site specific response to perturbed collagen.

ABSTRACT: Compromises to collagen and mineral lead to a decrease in whole bone quantity and quality in a variety of systemic diseases, yet, clinically, disease manifestations differ between craniofacial and long bones. Collagen alterations can occur through post-translational modification via lysyl oxidase (LOX), which catalyzes enzymatic collagen cross-link formation, as well as through non-enzymatic advanced glycation end products (AGEs) such as pentosidine and carboxymethyl-lysine (CML). Characterization of the cross-links and AGEs, and comparison of the mineral and collagen modifications in craniofacial and long bones represent a critical gap in knowledge. However, alterations to either the mineral or collagen in bone may contribute to disease progression and, subsequently, the anatomical site d

SUBMITTER: Romanowicz GE 

PROVIDER: S-EPMC9618783 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature