Alpha to Omicron: Disease Severity and Clinical Outcomes of Major SARS-CoV-2 Variants.

ABSTRACT:

Background

Four severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants predominated in the United States since 2021. Understanding disease severity related to different SARS-CoV-2 variants remains limited.

Method

Viral genome analysis was performed on SARS-CoV-2 clinical isolates circulating March 2021 through March 2022 in Cleveland, Ohio. Major variants were correlated with disease severity and patient outcomes.

Results

In total 2779 patients identified with either Alpha (n 1153), Gamma (n 122), Delta (n 808), or Omicron variants (n 696) were selected for analysis. No difference in frequency of hospitalization, intensive care unit (ICU) admission, and death were found among Alpha, Gamma, and Delta variants. However, patients with Omicron infection wer

SUBMITTER: Esper FP 

PROVIDER: S-EPMC9619650 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature