Dataset Information

Identification of a Novel Long Non-coding RNA, lnc-ATMIN-4:2, and its Clinicopathological and Prognostic Significance in Advanced Gastric Cancer.

ABSTRACT:

Background/aim

Long non-coding RNAs (lncRNAs) are emerging as significant regulators of gene expression and a novel promising biomarker for cancer diagnosis and prognosis. This study identified a novel, differentially expressed lncRNA in advanced gastric cancer (AGC), Inc-ATMIN-4:2, and evaluated its clinicopathological and prognostic significance.

Patients and methods

Whole transcriptome sequencing was performed to identify differentially expressed lncRNAs in AGC tissue samples. We also analyzed lnc-ATMIN-4:2 expression in 317 patients with AGC using RNA in situ hybridization.

Results

High (>30 dots) lnc-ATMIN-4:2 expression significantly correlated with younger age, poorly differentiated histology, diffuse type, deeper invasion depth, perineural invasion, lymph node metastasis, and higher stage group. In addition, high lnc-ATMIN-4:2 expression was significantly associated with worse overall survival in patients with AGC.

Conclusion

This study elucidated the significance of lncRNAs in AGC and indicated the value of lnc-ATMIN-4:2 expression as a predictive biomarker for the overall survival of patients with AGC.

SUBMITTER: Kim E

PROVIDER: S-EPMC9620448 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature

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Publications

Identification of a Novel Long Non-coding RNA, <i>lnc-ATMIN-4:2</i>, and its Clinicopathological and Prognostic Significance in Advanced Gastric Cancer.

Kim Eojin E Kim Hyunjin H Yeo Min-Kyung MK Kim Chul Hwan CH Kim Joo Young JY Park Sungsoo S Kim Hyun-Soo HS Chae Yang-Seok YS

Cancer genomics & proteomics 20221101 6

<h4>Background/aim</h4>Long non-coding RNAs (lncRNAs) are emerging as significant regulators of gene expression and a novel promising biomarker for cancer diagnosis and prognosis. This study identified a novel, differentially expressed lncRNA in advanced gastric cancer (AGC), Inc-ATMIN-4:2, and evaluated its clinicopathological and prognostic significance.<h4>Patients and methods</h4>Whole transcriptome sequencing was performed to identify differentially expressed lncRNAs in AGC tissue samples. ...[more]

PMID: 36316044

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