Ontology highlight
ABSTRACT: Background/aim
Long non-coding RNAs (lncRNAs) are emerging as significant regulators of gene expression and a novel promising biomarker for cancer diagnosis and prognosis. This study identified a novel, differentially expressed lncRNA in advanced gastric cancer (AGC), Inc-ATMIN-4:2, and evaluated its clinicopathological and prognostic significance.Patients and methods
Whole transcriptome sequencing was performed to identify differentially expressed lncRNAs in AGC tissue samples. We also analyzed lnc-ATMIN-4:2 expression in 317 patients with AGC using RNA in situ hybridization.Results
High (>30 dots) lnc-ATMIN-4:2 expression significantly correlated with younger age, poorly differentiated histology, diffuse type, deeper invasion depth, perineural invasion, lymph node metastasis, and higher stage group. In addition, high lnc-ATMIN-4:2 expression was significantly associated with worse overall survival in patients with AGC.Conclusion
This study elucidated the significance of lncRNAs in AGC and indicated the value of lnc-ATMIN-4:2 expression as a predictive biomarker for the overall survival of patients with AGC.
SUBMITTER: Kim E
PROVIDER: S-EPMC9620448 | biostudies-literature | 2022 Nov-Dec
REPOSITORIES: biostudies-literature
Kim Eojin E Kim Hyunjin H Yeo Min-Kyung MK Kim Chul Hwan CH Kim Joo Young JY Park Sungsoo S Kim Hyun-Soo HS Chae Yang-Seok YS
Cancer genomics & proteomics 20221101 6
<h4>Background/aim</h4>Long non-coding RNAs (lncRNAs) are emerging as significant regulators of gene expression and a novel promising biomarker for cancer diagnosis and prognosis. This study identified a novel, differentially expressed lncRNA in advanced gastric cancer (AGC), Inc-ATMIN-4:2, and evaluated its clinicopathological and prognostic significance.<h4>Patients and methods</h4>Whole transcriptome sequencing was performed to identify differentially expressed lncRNAs in AGC tissue samples. ...[more]