Into the future: A pilot study combining imaging with molecular profiling to predict resectability in ovarian cancer.

ABSTRACT:

Objective

We sought to determine the predictive value of combining tumor molecular subtype and computerized tomography (CT) imaging for surgical outcomes after primary cytoreductive surgery in advanced stage high-grade serous ovarian cancer (HGSOC) patients.

Methods

We identified 129 HGSOC patients who underwent pre-operative CT imaging and post-operative tumor mRNA profiling. A continuous CT-score indicative of overall disease burden was defined based on six imaging measurements of anatomic involvement. Molecular subtypes were derived from mRNA profiling of chemo-naïve tumors and classified as mesenchymal (MES) subtype (36%) or non-MES subtype (64%). Fischer exact tests and multivariate logistic regression examined residual disease and surgical complexity.

Results

Wo

SUBMITTER: Kumar A 

PROVIDER: S-EPMC9620550 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature