Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke.

ABSTRACT:

Background and objectives

Current genome-wide association studies of ischemic stroke have focused primarily on late onset disease. As a complement to these studies, we sought to identifythe contribution of common genetic variants to risk of early onset ischemic stroke.

Methods

We performed a meta-analysis of genome-wide association studies of early onset stroke (EOS), ages 18-59, using individual level data or summary statistics in 16,730 cases and 599,237 non-stroke controls obtained across 48 different studies. We further compared effect sizes at associated loci between EOS and late onset stroke (LOS) and compared polygenic risk scores for venous thromboembolism between EOS and LOS.

Results

We observed genome-wide significant associations of EOS with two variants in

SUBMITTER: Jaworek T 

PROVIDER: S-EPMC9620803 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature