Circulating MicroRNA Panel as a Diagnostic Marker for Hepatocellular Carcinoma.

ABSTRACT:

Background

Current diagnostic markers for hepatocellular carcinoma are compromised and limited by their low sensitivity and speci- ficity. In this study, circulating microRNAs were utilized as a diagnostic tool to segregate hepatocellular carcinoma patients from healthy subjects.

Methods

We analyzed 2 public datasets for differences in plasma microRNA expression profiles of hepatocellular carcinoma patients and healthy controls to identify biomarkers related to hepatocellular carcinoma. Plasma samples from hepatocellular carcinoma patients and control subjects were then collected for next-generation microRNA sequencing analysis. The differential microRNAs obtained from the above 3 parts were intersected to obtain microRNAs that were significantly different between the 2 grou

SUBMITTER: Wu X 

PROVIDER: S-EPMC9623203 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature