Dataset Information

Current ecotoxicity testing needs among selected U.S. federal agencies.

ABSTRACT: U.S. regulatory and research agencies use ecotoxicity test data to assess the hazards associated with substances that may be released into the environment, including but not limited to industrial chemicals, pharmaceuticals, pesticides, food additives, and color additives. These data are used to conduct hazard assessments and evaluate potential risks to aquatic life (e.g., invertebrates, fish), birds, wildlife species, or the environment. To identify opportunities for regulatory uses of non-animal replacements for ecotoxicity tests, the needs and uses for data from tests utilizing animals must first be clarified. Accordingly, the objective of this review was to identify the ecotoxicity test data relied upon by U.S. federal agencies. The standards, test guidelines, guidance documents, and/or endpoints that are used to address each of the agencies' regulatory and research needs regarding ecotoxicity testing are described in the context of their application to decision-making. Testing and information use, needs, and/or requirements relevant to the regulatory or programmatic mandates of the agencies taking part in the Interagency Coordinating Committee on the Validation of Alternative Methods Ecotoxicology Workgroup are captured. This information will be useful for coordinating efforts to develop and implement alternative test methods to reduce, refine, or replace animal use in chemical safety evaluations.

SUBMITTER: Ceger P

PROVIDER: S-EPMC9623878 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Current ecotoxicity testing needs among selected U.S. federal agencies.

Ceger Patricia P Garcia-Reyero Vinas Natalia N Allen David D Arnold Elyssa E Bloom Raanan R Brennan Jennifer C JC Clarke Carol C Eisenreich Karen K Fay Kellie K Hamm Jonathan J Henry Paula F P PFP Horak Katherine K Hunter Wesley W Judkins Donna D Klein Patrice P Kleinstreuer Nicole N Koehrn Kara K LaLone Carlie A CA Laurenson James P JP Leet Jessica K JK Lowit Anna A Lynn Scott G SG Norberg-King Teresa T Perkins Edward J EJ Petersen Elijah J EJ Rattner Barnett A BA Sprankle Catherine S CS Steeger Thomas T Warren Jim E JE Winfield Sarah S Odenkirchen Edward E

Regulatory toxicology and pharmacology : RTP 20220602

U.S. regulatory and research agencies use ecotoxicity test data to assess the hazards associated with substances that may be released into the environment, including but not limited to industrial chemicals, pharmaceuticals, pesticides, food additives, and color additives. These data are used to conduct hazard assessments and evaluate potential risks to aquatic life (e.g., invertebrates, fish), birds, wildlife species, or the environment. To identify opportunities for regulatory uses of non-anima ...[more]

PMID: 35660046

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Project description:ContextSyndromic surveillance consists of the systematic collection and use of near real-time data about health-related events for situational awareness and public health action. As syndromic surveillance programs continue to adopt new technologies and expand, it is valuable to evaluate these syndromic surveillance systems and practices to ensure that they meet public health needs.ObjectiveThis assessment's aim is to provide recent information about syndromic surveillance systems and practice characteristics among a group of state and local health departments.Design/settingInformation was obtained between November 2017 and June 2018 through a telephone survey using an Office of Management and Budget-approved standardized data collection tool. Participants were syndromic surveillance staff from each of 31 state and local health departments participating in the National Syndromic Surveillance Program funded by the Centers for Disease Control and Prevention. Questions included jurisdictional experience, data sources and analysis systems used, syndromic system data processing characteristics, data quality verification procedures, and surveillance activities conducted with syndromic data.MeasuresPractice-specific information such as types of systems and data sources used for syndromic surveillance, data quality monitoring, and uses of data for public health situational awareness (eg, investigating occurrences of or trends in diseases).ResultsThe survey analysis revealed a wide range of experiences with syndromic surveillance. Participants reported the receipt of data daily or more frequently. Emergency department data were the primary data source; however, other data sources are being integrated into these systems. All health departments routinely monitored data quality. Syndromes of highest priority across the respondents for health events monitoring were influenza-like illness and drug-related syndromes. However, a wide variety of syndromes were reported as priorities across the health departments.ConclusionOverall, syndromic surveillance was relevantly integrated into the public health surveillance infrastructure. The near real-time nature of the data and its flexibility to monitor different types of health-related issues make it especially useful for public health practitioners. Despite these advances, syndromic surveillance capacity, locally and nationally, must continue to evolve and progress should be monitored to ensure that syndromic surveillance systems and data are optimally able to meet jurisdictional needs.

Dataset Information

Current ecotoxicity testing needs among selected U.S. federal agencies.

Publications

Current ecotoxicity testing needs among selected U.S. federal agencies.

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