Lp(a), oxidized phospholipids and oxidation-specific epitopes are increased in subjects with keloid formation.

ABSTRACT:

Background

Keloid formation following trauma or surgery is common among darkly pigmented individuals. Since lipoprotein(a) [Lp(a)] has been postulated to have a putative role in wound healing, and also mediates atherosclerotic cardiovascular disease, it was assessed whether Lp(a), its associated oxidized phospholipids and other oxidation-specific biomarkers were associated with keloid formation.

Methods

This case-control study included darkly pigmented individuals of African ancestry, 100 with keloid scarring and 100 non-keloid controls. The lipid panel, hsCRP, Lp(a), oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB), IgG and IgM apoB-immune complexes and IgG and IgM autoantibodies to a malondialdehyde mimotope (MDA-mimotope) were measured. Immunohistochemistry of k

SUBMITTER: Ruder S 

PROVIDER: S-EPMC9623907 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature