Levels of soluble complement regulators predict severity of COVID-19 symptoms.

ABSTRACT: The SARS-CoV-2 virus continues to cause significant morbidity and mortality worldwide from COVID-19. One of the major challenges of patient management is the broad range of symptoms observed. While the majority of individuals experience relatively mild disease, a significant minority of patients require hospitalisation, with COVID-19 still proving fatal for some. As such, there remains a desperate need to better understand what drives this severe disease, both in terms of the underlying biology, but also to potentially predict at diagnosis which patients are likely to require further interventions, thus enabling better outcomes for both patients and healthcare systems. Several lines of evidence have pointed to dysregulation of the complement cascade as a major factor in severe COVID-19 out

SUBMITTER: Tierney AL 

PROVIDER: S-EPMC9624227 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature