Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis.

ABSTRACT:

Background and objectives

Uromodulin, produced exclusively in the kidney's thick ascending limb, is a biomarker of kidney tubular health. However, the relationship between urine uromodulin and histologic changes in the kidney tubulointerstitium has not been characterized. In this study, we test the association of urine uromodulin with kidney histologic findings in humans and mice.

Design, setting, participants, & measurements

We investigated the independent association of urine uromodulin measured at the time of kidney biopsy with histologic features in 364 participants at two academic medical centers from 2015 to 2018 using multivariable linear regression models. This relationship was further examined by comparison of uromodulin staining in murine models of kidney fibrosis

SUBMITTER: Melchinger H 

PROVIDER: S-EPMC9625093 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature