Association of GLP1R variants rs2268641 and rs6923761 with obesity and other metabolic parameters in a Polish cohort.

ABSTRACT:

Introduction

Obesity is a complex disease associated with excessive fat accumulation and numerous metabolic complications. So far, many factors leading to the development of this disorder have been identified, including genetic susceptibility. Various studies linked GLP1R variants with anthropometric and metabolic parameters, suggesting the role of the variation in this gene in metabolic health.

Objective

The aim of this study is to investigate the association of two single nucleotide variants of GLP1R gene, rs2268641 and rs6923761, with excessive weight, metabolic syndrome, anthropometric measurements and selected metabolic parameters.

Methods

Normal-weight subjects (n= 340, control group) and subjects with excessive body mass (n = 600, study group) par

SUBMITTER: Michalowska J 

PROVIDER: S-EPMC9626533 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature