Immune Phenotypes and Target Antigens of Clonally Expanded Bone Marrow T Cells in Treatment-Naive Multiple Myeloma.

ABSTRACT: Multiple myeloma is a hematologic malignancy of monoclonal plasma cells that accumulate in the bone marrow. Despite their clinical and pathophysiologic relevance, the roles of bone marrow-infiltrating T cells in treatment-naïve patients are incompletely understood. We investigated whether clonally expanded T cells (i) were detectable in multiple myeloma bone marrow, (ii) showed characteristic immune phenotypes, and (iii) whether dominant clones recognized antigens selectively presented on multiple myeloma cells. Single-cell index sorting and T-cell receptor (TCR) αβ sequencing of bone marrow T cells from 13 treatment-naïve patients showed dominant clonal expansion within CD8+ cytolytic effector compartments, and only a minority of expanded T-cell clones expressed the classic immune-checkpo

SUBMITTER: Welters C 

PROVIDER: S-EPMC9627264 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature