Substantially Elevated Atherosclerotic Risks in Japanese Severe Familial Hypercholesterolemia Defined by the International Atherosclerosis Society

ABSTRACT:

Background

The International Atherosclerosis Society (IAS) has proposed “severe familial hypercholesterolemia” (FH) as a phenotype with the highest cardiovascular risk. However, whether this criteria could appropriately stratify a high-risk Japanese patient with FH remains unknown.

Objectives

This study sought to characterize atherosclerotic cardiovascular diseases in IAS-defined Japanese subjects with severe FH.

Methods

This study analyzed 380 clinically diagnosed subjects with heterozygous FH without any history of atherosclerotic cardiovascular diseases. Severe FH was defined as untreated low-density lipoprotein cholesterol >400 mg/dL, >310 mg/dL plus 1 high-risk feature, or >190 mg/dL plus 2 high-risk features according to IAS-proposed statement. The occurren

SUBMITTER: Funabashi S 

PROVIDER: S-EPMC9627852 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature