Genome-wide Association Study of Postburn Scarring Identifies a Novel Protective Variant.

ABSTRACT:

Objective

To identify genetic variants associated with the severity of postburn hypertrophic scarring (HTS) using a genome-wide approach.

Background

Risk of severe postburn HTS is known to depend on race, but the genetic determinants of HTS are unknown.

Methods

We conducted a genome-wide association study (GWAS) in a prospective cohort of adults admitted with deep-partial-thickness burns from 2007 through 2014. Scar severity was assessed over time using the Vancouver Scar Scale (VSS), and DNA was genotyped with a >500,000-marker array. We performed association testing of single-nucleotide polymorphisms (SNPs) with minor allele frequency (MAF) >0.01 using linear regression of VSS height score on genotype adjusted for patient and injury characteristics as well as popula

SUBMITTER: Sood RF 

PROVIDER: S-EPMC9632222 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature