Novelty-induced locomotor behavior predicts heroin addiction vulnerability in male, but not female, rats.

ABSTRACT:

Rationale

The ongoing rise in opioid use disorder (OUD) has made it imperative to better model the individual variation within the human population that contributes to OUD vulnerability. Using animal models that capture such variation can be a useful tool. Individual variation in novelty-induced locomotion is predictive of substance use disorder (SUD) propensity. In this model, rats are characterized as high-responders (HR) or low-responders (LR) using a median split based on distance travelled during a locomotor test, and HR rats are generally found to exhibit a more SUD vulnerable behavioral phenotype.

Objectives

The HR/LR model has commonly been used to assess behaviors in male rats using psychostimulants, with limited knowledge of the predictive efficacy of this model in

SUBMITTER: Kuhn BN 

PROVIDER: S-EPMC9632364 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature