Association between germline pathogenic variants in cancer-predisposing genes and lymphoma risk.

ABSTRACT: The application of advanced molecular technology has significantly expanded lymphoma classification, allowing risk stratification and treatment optimization. Limited evidence suggests the presence of a genetic predisposition in lymphoma, indicating the potential for better individualized clinical management based on a novel lymphoma classification. Herein, we examined the impact of germline pathogenic variants in 27 cancer-predisposing genes with lymphoma risk and explored the clinical characteristics of pathogenic variant carriers. This study included 2,066 lymphoma patients and 38,153 cancer-free controls from the Japanese population. Following quality control of sequencing data, samples from 1,982 lymphoma patients and 37,592 controls were further analyzed. We identified 309 pathogenic

SUBMITTER: Usui Y 

PROVIDER: S-EPMC9633290 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature