Plasma metabolomic signatures of obesity and risk of type 2 diabetes.

ABSTRACT:

Objective

The mechanisms linking obesity to type 2 diabetes (T2D) are not fully understood. This study aimed to identify obesity-related metabolomic signatures (MESs) and evaluated their relationships with incident T2D.

Methods

In a nested case-control study of 2076 Chinese adults, 140 plasma metabolites were measured at baseline, linear regression was applied with the least absolute shrinkage and selection operator to identify MESs for BMI and waist circumference (WC), and conditional logistic regression was applied to examine their associations with T2D risk.

Results

A total of 32 metabolites associated with BMI or WC were identified and validated, among which 14 showed positive associations and 3 showed inverse associations with T2D; 8 and 18 metabolites were selec

SUBMITTER: Pan XF 

PROVIDER: S-EPMC9633360 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature