Geographical distribution of host's specific SARS-CoV-2 mutations in the early phase of the COVID-19 pandemic.

ABSTRACT:

Purpose

To assess, if the SARS-CoV-2 mutate in a similar pattern globally or has a specific pattern in any given population.

Results

We report, the insertion of TTT at 11085, which adds an extra amino acid, F to the NSP6 at amino acid position 38. The highest occurrence of TTT insertion at 11,085 position was found in UK derived samples (65.97%). The second and third highest occurrence of the mutation were found in Australia (8.3%) and USA (4.16%) derived samples, respectively. Another important discovery of this study is the C27945T mutation, which translates into the termination of ORF-8 after 17 amino acids, reveals that the SARS-CoV-2 can replicate without the intact ORF-8 protein. We found that the 97% of C27945T mutation of global occurrence, occurred in Europe and the

SUBMITTER: Khalid M 

PROVIDER: S-EPMC9635256 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature