Dataset Information

Geographical distribution of host's specific SARS-CoV-2 mutations in the early phase of the COVID-19 pandemic.

ABSTRACT:

Purpose

To assess, if the SARS-CoV-2 mutate in a similar pattern globally or has a specific pattern in any given population.

Results

We report, the insertion of TTT at 11085, which adds an extra amino acid, F to the NSP6 at amino acid position 38. The highest occurrence of TTT insertion at 11,085 position was found in UK derived samples (65.97%). The second and third highest occurrence of the mutation were found in Australia (8.3%) and USA (4.16%) derived samples, respectively. Another important discovery of this study is the C27945T mutation, which translates into the termination of ORF-8 after 17 amino acids, reveals that the SARS-CoV-2 can replicate without the intact ORF-8 protein. We found that the 97% of C27945T mutation of global occurrence, occurred in Europe and the USA derived samples.

Conclusions

Two of the reported mutations (11085TTT insertion and C27945T nonsense), which seemed to reduce Type I interferon response are linked to specific geographical locations of the host and implicate region-specific mutations in the virus. The findings of this study signify that SARS-CoV-2 has the potential to adapt differently to different populations.

SUBMITTER: Khalid M

PROVIDER: S-EPMC9635256 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Geographical distribution of host's specific SARS-CoV-2 mutations in the early phase of the COVID-19 pandemic.

Khalid Mohammad M Murphy David D Shoai Maryam M George-William Jonahunnatha Nesson JN Al-Ebini Yousef Y

Gene 20221104

<h4>Purpose</h4>To assess, if the SARS-CoV-2 mutate in a similar pattern globally or has a specific pattern in any given population.<h4>Results</h4>We report, the insertion of TTT at 11085, which adds an extra amino acid, F to the NSP6 at amino acid position 38. The highest occurrence of TTT insertion at 11,085 position was found in UK derived samples (65.97%). The second and third highest occurrence of the mutation were found in Australia (8.3%) and USA (4.16%) derived samples, respectively. An ...[more]

PMID: 36343703

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Dataset Information

Geographical distribution of host's specific SARS-CoV-2 mutations in the early phase of the COVID-19 pandemic.

Purpose

Results

Conclusions

Publications

Geographical distribution of host's specific SARS-CoV-2 mutations in the early phase of the COVID-19 pandemic.

Similar Datasets

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