A chromosome-level assembly of the widely used Rockefeller strain of Aedes aegypti, the yellow fever mosquito.

ABSTRACT: Aedes aegypti is the vector of important human diseases, and genomic resources are crucial in facilitating the study of A. aegypti and its ecosystem interactions. Several laboratory-acclimated strains of this mosquito have been established, but the most used strain in toxicology studies is "Rockefeller," which was originally collected and established in Cuba 130 years ago. A full-length genome assembly of another reference strain, "Liverpool," was published in 2018 and is the reference genome for the species (AaegL5). However, genetic studies with the Rockefeller strain are complicated by the availability of only the Liverpool strain as the reference genome. Differences between Liverpool and Rockefeller have been known for decades, particularly in the expression of genes relevant to mosqui

SUBMITTER: Fisher CR 

PROVIDER: S-EPMC9635639 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature