Ontology highlight
ABSTRACT:
SUBMITTER: Zhao LH
PROVIDER: S-EPMC9637140 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Zhao Li-Hua LH Lin Jingyu J Ji Su-Yu SY Zhou X Edward XE Mao Chunyou C Shen Dan-Dan DD He Xinheng X Xiao Peng P Sun Jinpeng J Melcher Karsten K Zhang Yan Y Yu Xiao X Xu H Eric HE
Nature communications 20221105 1
The ability to couple with multiple G protein subtypes, such as G<sub>s</sub>, G<sub>i/o</sub>, or G<sub>q/11</sub>, by a given G protein-coupled receptor (GPCR) is critical for many physiological processes. Over the past few years, the cryo-EM structures for all 15 members of the medically important class B GPCRs, all in complex with G<sub>s</sub> protein, have been determined. However, no structure of class B GPCRs with G<sub>q/11</sub> has been solved to date, limiting our understanding of th ...[more]