First quantitative dosages: Strong correlations between non-5-HT₂Rs serotonin receptors on normal human heart valves.

ABSTRACT:

Objectives

Although critical in animal and human development and pathology, a measurement of the quantitative expression of 5-HTR serotonin receptors on animal or human valvular tissues has never been performed.

Methods

Quantification of the most frequent 5-HTRs reported as being present in human peripheral tissue was performed using radiolabeled agonists/antagonists. A membrane protein extract from normal human valves (aortic/mitral/tricuspid and some pulmonary) and associated diseased left myocardium, all unusable in clinics, were obtained from the Homograft bank.

Results

We analyzed 5-HT_1AR/5-HT_1B/DR/5-HT_2AR/5-HT_2BR/5-HT _2CR/5-HT₄R/5-HT₇R from 28 hearts. We confirmed the presence of tissue

SUBMITTER: Schussler O 

PROVIDER: S-EPMC9641165 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature