MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil.

ABSTRACT:

Background

Although aging correlates with a worse prognosis for Covid-19, super elderly still unvaccinated individuals presenting mild or no symptoms have been reported worldwide. Most of the reported genetic variants responsible for increased disease susceptibility are associated with immune response, involving type I IFN immunity and modulation; HLA cluster genes; inflammasome activation; genes of interleukins; and chemokines receptors. On the other hand, little is known about the resistance mechanisms against SARS-CoV-2 infection. Here, we addressed polymorphisms in the MHC region associated with Covid-19 outcome in super elderly resilient patients as compared to younger patients with a severe outcome.

Methods

SARS-CoV-2 infection was confirmed by RT-PCR test. Aimi

SUBMITTER: Castelli EC 

PROVIDER: S-EPMC9641602 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature