T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression.

ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving neuroinflammation and T cell infiltration in the central nervous system. However, the contribution of T cell responses to the pathology of the disease is not fully understood. Here we show, by flow cytometric analysis of blood and cerebrospinal fluid (CSF) samples of a cohort of 89 newly diagnosed ALS patients in Stockholm, Sweden, that T cell phenotypes at the time of diagnosis are good predictors of disease outcome. High frequency of CD4⁺FOXP3^- effector T cells in blood and CSF is associated with poor survival, whereas high frequency of activated regulatory T (Treg) cells and high ratio between activated and resting Treg cells in blood are associated with better survival. Besides sur

SUBMITTER: Yazdani S 

PROVIDER: S-EPMC9643478 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature