A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer.

ABSTRACT:

Background and objective

Breast cancer (BC) diagnosed at ages <40 years presents with more aggressive tumour phenotypes and poorer clinical outcome compared to older BC patients. Here, we explored transcriptional BC alterations to gain a better understanding of age-related tumour biology, also subtype-stratified.

Methods

We studied publicly available global BC mRNA expression (n = 3999) and proteomics data (n = 113), exploring differentially expressed genes, enriched gene sets, and gene networks in the young compared to older patients.

Results

We identified transcriptional patterns reflecting increased proliferation and oncogenic signalling in BC of the young, also in subtype-stratified analyses. Six up-regulated hub genes built a novel age-related score, significantl

SUBMITTER: Ingebriktsen LM 

PROVIDER: S-EPMC9643541 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature