An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis.

ABSTRACT:

Background

Without the availability of disease-modifying drugs, there is an unmet therapeutic need for osteoarthritic patients. During osteoarthritis, the homeostasis of articular chondrocytes is dysregulated and a phenotypical transition called hypertrophy occurs, leading to cartilage degeneration. Targeting this phenotypic transition has emerged as a potential therapeutic strategy. Chondrocyte phenotype maintenance and switch are controlled by an intricate network of intracellular factors, each influenced by a myriad of feedback mechanisms, making it challenging to intuitively predict treatment outcomes, while in silico modeling can help unravel that complexity. In this study, we aim to develop a virtual articular chondrocyte to guide experiments in order to rationalize the ident

SUBMITTER: Lesage R 

PROVIDER: S-EPMC9648005 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature