Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime.

ABSTRACT: Synthesis of new Cefpodoxime derivatives via Schiff Bases mechanism and the efficiency of their antimicrobial and antiviral activities were addressed. They were analyzed for structural validation by using spectroscopic techniques using FTIR, ¹HNMR, and ¹³CNMR. Molecular docking against IBV Virus papain-like protease (PLPro) was done with Auto dock tools against compounds having excellent IC₅₀ values against IBV (Corona Class) virus. All derivatives showed strong zone of inhibition ranges from (55 ± 2.0 to 70 ± 0.8 mm) against E. coli. Compounds 1,2,4 and 6 derivatives showed remarkable activity against Stenotrophomonas maltophilia and Serratia marcescens. But For most the newly synthesized derivatives C ¹ (64 ±

SUBMITTER: Mahmood W 

PROVIDER: S-EPMC9649975 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature