Co-ultramicronized palmitoylethanolamide/luteolin normalizes GABA_B-ergic activity and cortical plasticity in long COVID-19 syndrome.

ABSTRACT:

Objective

Transcranial magnetic stimulation (TMS) studies showed that patients with cognitive dysfunction and fatigue after COVID-19 exhibit impaired cortical GABA_B-ergic activity, as revealed by reduced long-interval intracortical inhibition (LICI). Aim of this study was to test the effects of co-ultramicronized palmitoylethanolamide/luteolin (PEA-LUT), an endocannabinoid-like mediator able to enhance GABA-ergic transmission and to reduce neuroinflammation, on LICI.

Methods

Thirty-nine patients (26 females, mean age 49.9 ± 11.4 years, mean time from infection 296.7 ± 112.3 days) suffering from persistent cognitive difficulties and fatigue after mild COVID-19 were randomly assigned to receive either PEA-LUT 700 mg + 70 mg or PLACEBO, administered orally bid for ei

SUBMITTER: Versace V 

PROVIDER: S-EPMC9650483 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature